Abstract Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer with an appalling overall survival of less than 5% (Zimmerman et al.J Thor Oncol 14:768-83, 2019).Patients typically respond to front line platinum-based doublet chemotherapy, Firewire but almost universally relapse with drug resistant disease.Elevated MYC expr
Background.Animals acquire new skills due to conditioned responses resulting from a sequence of neutral and unconditioned stimuli affecting their bodies; there is a constant time interval between the stimuli.Both stimuli become associated after a number of repetitions and animal bodies start to respond to the initially neutral stimulus as to the un
The biocontrol of soilborne plant Short Grey Birds on Cross- Cast Iron pathogens represents a promising approach from the environ- mental and practical points of view.Fluorescent pseudomonad rhizobacteria are well known by their antagonis- tic capacity towards several plant pathogens due to a diversity of antimicrobial metabolites they produce.This
Lane-changing (LC) is a critical task for autonomous driving, especially in complex dynamic environments.Numerous automatic LC algorithms have been proposed.This topic, however, has not been sufficiently addressed in existing on-road manoeuvre decision methods.Therefore, this paper presents a novel LC decision (LCD) model that gives autonomous vehi
In the present study, we attempted to control the pH profile of the catalytic activity of the industrially relevant alkaline protease KP-43, by incorporating 3-nitro-l-tyrosine and 3-chloro-l-tyrosine at and near the catalytic site.Thirty KP-43 variants containing these non-natural amino acids at the specific positions were synthesized in Escherich